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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 16-Apr-21
CAEL101-301
AL (or light chain) amyloidosis begins in the bone marrow where abnormal proteins misfold and create free light chains that cannot be broken down. These free light chains bind together to form amyloid fibrils that build up in the extracellular space of organs, affecting the kidneys, heart, liver, spleen, nervous system and digestive tract. The primary purpose of this study is to determine if CAEL-101 improves the overall survival in Patients with cardiac AL Amyloidosis.
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 07-Apr-21
(ROCHE) WO41554/INAVO120
Study WO41554 is a Phase III, randomized, double-blind, placebo-controlled, multicenter, global study designed to compare the efficacy, as measured by PFS, and the safety of the triplet combination of GDC-0077 plus palbociclib and fulvestrant versus placebo plus palbociclib and fulvestrant in patients with PIK3CA-mutant, HR-positive, HER2-negative locally advanced or metastatic breast cancer whose disease progressed during treatment or within 12 months of completing adjuvant endocrine therapy and who have not received prior systemic therapy for locally advanced or metastatic disease.
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CANCER TYPE: Gastrointestinal
LOCATION: Edmonton
OPEN DATE: 07-Apr-21
D-US-60010-001
The purpose of this study is to look at the efficacy and safety of Irinotecan liposome injection in combination with other approved drugs used for cancer therapy, namely 5 fluorouracil/leucovorin (5FU/LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for metastatic pancreatic cancer.
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CANCER TYPE: Melanoma
LOCATION: Edmonton
OPEN DATE: 31-Mar-21
Array-818-201
This is a multicenter, randomized open-label Phase 2 study to assess the safety, efficacy and pharmacokinetic (PK) of 2 dosing regimens of encorafenib + binimetinib combination in patients with BRAFV600-mutant melanoma with brain metastasis. Approximately 100 patients will be enrolled, including 9 patients in a Safety Lead-in of the high-dose treatment arm. After a Screening Period, treatment will be administered in 28-day cycles and will continue until disease progression, unacceptable toxicity, withdrawal of consent, start of subsequent anticancer therapy, death.
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CANCER TYPE: Melanoma
LOCATION: Edmonton
OPEN DATE: 30-Mar-21
IIT-0003 ACT-FAST
An interventional, randomized phase II study investigating the efficacy of immune checkpoint inhibitors while corticosteroid therapy is required for patients with symptomatic brain metastases
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 25-Mar-21
(Seattle Genetics) SGN22E-003 / EV-302
This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have cancer that has spread from their urinary system to other parts of their body.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 23-Mar-21
1951-CL-0101
A Phase 1b Study of ASP1951, a GITR Agonistic Antibody, as a Single Agent and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors
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CANCER TYPE: Neuro
LOCATION: Calgary
OPEN DATE: 18-Mar-21
(AHS) Phase I-II Niacin in GB
This is a single institution Phase I-II study to evaluate the tolerability and Maximum Tolerated Dose (MTD) (Phase I) and efficacy (Phase II) of adding Niacin CRT™ to standard first line treatment (concurrent Radiation Therapy (RT) and Temozolomide (TMZ) following by monthly TMZ - AKA Stupp protocol) in patients with newly diagnosed glioblastoma isocitrate dehydrogenase (IDH) wild type. During the Phase I stage Niacin CRT™ dose will be escalated every 4 weeks until the maximum tolerated dose (MTD) is determined. The MTD dose will be prescribed to patients during the Phase II stage. Up to 59 patients will be included (depending on the toxicity patients experience). Expected toxicity include flushing that is ameliorated by the proposed escalation and formulation used. Special attention will be paid to liver and bone marrow toxicity that may be increased with this combination. This is a first in humans study so unexpected toxicities may be possible. During the Phase I study a sample of blood at baseline, at each level dose of Niacin CRT™, and every two months during the maintenance phase while on Niacin CRT™ will be sent to a lab to evaluate the peripheral activity of Niacin CRT™ in innate immune system cells.
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CANCER TYPE: Radiation Therapy
LOCATION: Edmonton
OPEN DATE: 09-Mar-21
IIT-0008/CRAVE
A Phase II Randomized Trial of Combined Radiotherapy and Vertebroplasty to Improve the Quality of Life of Patients With Painful Metastatic Localized Spinal Lesions
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 05-Mar-21
SGN35-015
A phase 2 open-label study of brentuximab vedotin in front-line therapy of Hodgkin lymphoma (HL) and CD30- expressing peripheral T-cell lymphoma (PTCL) in older patients or patients with significant comorbidities ineligible for standard chemotherapy
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 03-Mar-21
ACIT001/EXC002
A Phase 1b/2 Multi-center, De-centralized, Dose Selection Study of Autologous CD19-directed Chimeric Antigen Receptor (CAR) T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 01-Mar-21
PAC203
A Phase 2/3 Study of Pacritinib in Patients with Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 01-Mar-21
AbbVie-M16-109 - MF
A Phase 2 Open-Label Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination with Ruxolitinib in Subjects with Myelofibrosis
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CANCER TYPE: Other
LOCATION: Edmonton
OPEN DATE: 01-Mar-21
MENAC
Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. There is an urgency for improving management, but there is no consensus on the optimal treatment for cancer cachexia. Several single therapies for cancer cachexia have been examined in clinical trials, with disappointing overall results. As multiple factors are responsible for the development of cachexia, it has been argued that optimal cachexia interventions should target all components: multimodal therapy for a multimodal problem. The overall aim of this study is to early prevent the development of cachexia rather than treatment late in the disease trajectory. From a patient perspective a short term effect will be to improve physical and psychological function, to reduce symptom burden and to improve survival. In other words live a longer and better life during and after chemotherapy. Direct effects of the cachexia intervention are expected to be reduction of weight and muscle loss, and improved physical activity and quality of life.
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CANCER TYPE: Other
LOCATION: Edmonton
OPEN DATE: 26-Feb-21
IIT-0018 (PROTECT)
The PROTECT Study: Pressure injuRy preventiOn byinTermittent EleCtrical sTimulation
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 26-Feb-21
20190131
To evaluate the safety and tolerability of AMG 650 in adult participants and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 25-Feb-21
APL-101-01
The primary Phase 1 purpose of this study is to assess overall safety and tolerability and recommended Phase 2 dose (RP2D) of APL-101. The Phase 2 portion will assess efficacy of the dose determined in Phase 1 in individuals with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
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CANCER TYPE: Radiation Therapy
LOCATION: Edmonton
OPEN DATE: 23-Feb-21
ASPIRE-ILD
Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease (ASPIRE-ILD): A Phase II Trial. This is a prospective phase II study of SABR in patients with co-existent interstitial lung disease, to determine oncologic and toxicity outcomes. Patients will be divided into 3 separate cohorts based on the ILD-GAP index.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 18-Feb-21
(AbbVie) M13-494
A study designed to evaluate the safety and efficacy of venetoclax plus dexamethasone (VenDex) compared with pomalidomide plus dexamethasone (PomDex) in participants with t(11;14)-positive Relapsed or Refractory Multiple Myeloma.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 11-Feb-21
ALKS 4230-001
A Phase 1/2 Study of ALKS 4230 Administered Subcutaneously as Monotherapy and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors
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CANCER TYPE: Head and Neck
LOCATION: Calgary
OPEN DATE: 10-Feb-21
(Merck) MK7902-009
This study is designed to assess the safety and efficacy of lenvatinib in combination with pembrolizumab versus standard of care (SOC) chemotherapy, and to also assess the safety and efficacy of lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and a programmed cell death protein 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) inhibitor. The primary hypothesis is that pembrolizumab + lenvatinib is superior to SOC chemotherapy with respect to ORR per modified Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by blinded independent central review.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 10-Feb-21
M16-573
A Phase 1 First-in-Human Study with ABBV-155 Aloneand in Combination with Taxane Therapy in Adults with Relapsed and/or Refractory Solid Tumors
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 04-Feb-21
XL184-315 (Contact-02)
A Phase 3, Randomized, Open-Label, Controlled Study of Cabozantinib (XL184) in Combination with Atezolizumab vs Second Novel Hormonal Therapy (NHT) in Subjects with Metastatic Castration-Resistant Prostate Cancer
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 04-Feb-21
64007957MMY1001
A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study of Teclistamab, a Humanized BCMA x CD3 Bispecific Antibody, in Subjects with Relapsed or Refractory Multiple Myeloma.
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CANCER TYPE: Lung
LOCATION: Calgary
OPEN DATE: 01-Feb-21
(Amgen) 20190009 AMG510
A Phase 3 Multicenter, Randomized, Open Label, Active-controlled, Study of AMG 510 Versus Docetaxel for the Treatment of Previously Treated Locally Advanced and Unresectable or Metastatic NSCLC Subjects With Mutated KRAS p.G12C
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 29-Jan-21
(Janssen) 64407564MMY1002 TRIMM-2
A Phase 1b Study of Subcutaneous Daratumumab Regimens in Combination with Bispecific T Cell Redirection Antibodies for the Treatment of Subjects with Multiple Myeloma. The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab with or without pomalidomide) and to characterize the safety of each RP2D for selected treatment combinations.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 21-Jan-21
OCEL-01
A Phase 1b/2a Two-Part, Open-Label, Multicenter Study to Evaluate the Safety and Pharmacokinetics of OC-001 as Monotherapy and in Combination with an anti-PD- 1/anti-PD-L1 Antibody in Patients with Selected Locally Advanced or Metastatic Cancers
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CANCER TYPE: Cutaneous
LOCATION: Calgary
OPEN DATE: 15-Jan-21
(BMS) CA209-76K
The purpose of this study is to determine the effectiveness of nivolumab adjuvant immunotherapy compared to placebo in adults and pediatric participants after complete resection of Stage IIB/C melanoma with no evidence of disease (NED) who are at high risk for recurrence.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 07-Jan-21
ALLO-BAT study
The purpose of this research study is to see how effective hematopoietic stem cell transplantation (HCT) is compared to best available non-transplant therapies (BAT) in patients with high risk myelofibrosis. This will be done by asking participants to choose the treatment that they prefer to receive (HCT or BAT) and then comparing the outcomes of the participants in both treatment groups.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 04-Jan-21
CCTG BL 13
A Randomized Phase II trial assessing trimodality therapy with or without adjuvant Durvalumab (medi4736) to treat patients with muscle-invasive bladder cancer. The purpose of this study is to find out what effects durvalumab has on bladder cancer, combined with treatment after completion of surgery, chemotherapy and radiotherapy.
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 30-Dec-20
(Zymeworks) ZWI-ZW25-202
This is a multicenter, Phase 2a, open-label, 2-part study to investigate the safety, tolerability, and anti-tumor activity of ZW25 (zanidatamab) in combination with palbociclib plus fulvestrant. Eligible patients include those with locally advanced (unresectable) and/or metastatic human epidermal growth factor receptor 2 (HER2)-positive, hormone receptor (HR)-positive breast cancer.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 22-Dec-20
AREN1921
Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumor (FHWT)
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 21-Dec-20
J2G-MC-JZJC
The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease have the option to potentially crossover to selpercatinib.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 17-Dec-20
CVPM087A2101
The purpose of the study is to determine the pharmacodynamically active dose (PAD) of gevokizumab monotherapy, to determine tolerable dose of gevokizumab in combination with the standard of care (SOC) anti-cancer therapies in patients with mCRC, mGEC and mRCC, and to explore the hypothesis that dual blockade of VEGF and IL-1β signaling by combination of established anti-angiogenic therapies and gevokizumab will result in enhanced anti-tumor effect compared to the SOC anti-cancer therapies
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 16-Dec-20
(Janssen) 64007957MMY1001-P3
A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study of Teclistamab, a Humanized BCMA x CD3 Bispecific Antibody, in Subjects with Relapsed or Refractory Multiple Myeloma.
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 26-Nov-20
(NuCana) NuTide121
A Phase III Open-Label, Multi-Centre, Randomized Study Comparing NUC-1031 plus Cisplatin to Gemcitabine plus Cisplatin in Patients with Previously Untreated Locally Advanced or Metastatic Biliary Tract Cancer
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CANCER TYPE: Breast
LOCATION: Edmonton
OPEN DATE: 17-Nov-20
TRIO 036
A Trial to Assess the Safety, Pharmacodynamic Effects, Pharmacokinetics and Efficacy of the MNK Inhibitor Tomivosertib (eFT508) in Combination with Paclitaxel Following a Run-In Period of Tomivosertib Monotherapy, in Patients with Advanced Breast Cancer
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 13-Nov-20
(CCTG) CRC.9 / NRG-GI005
a Phase II/III Study is designed to determine whether to recommend chemotherapy or no further treatment after surgery for an early stage colon cancer, by taking a blood sample and testing for the presence of circulating tumour DNA (ctDNA)
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 02-Nov-20
AALL1931
AALL1931 An Open-Label Multicenter Study of RC-P in Patients with Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma Following Hypersensitivity to E.coli-derived Asparaginses
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 28-Oct-20
GSK207503 DREAMM-7
A Multicenter, Open-Label, Randomized Phase III Study to Evaluate the Efficacy and Safety of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (B-Vd) Compared With the Combination of Daratumumab, Bortezomib and Dexamethasone (D-Vd) in Participants With Relapsed/Refractory Multiple Myeloma
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 28-Oct-20
CCTG IND.238
A Phase II Study is to determine if patients who discontinued immunotherapy due to severe side effects related to treatment can be safely retreated with durvalumab at the time of disease progression and to investigate whether prophylactic steroid use can prevent or reduce new or recurrent side effects. This study will also examine response, progression free survival and explore the relationship between certain biomarkers and outcomes of treatment.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 27-Oct-20
GSK 209664 DREAMM 9
This study will evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of belantamab mafodotin in combination with Velcade (bortezomib), Revlimid (lenalidomide), dexamethasone (VRd) and will determine recommended phase 3 dose (RP3D) in adult participants with newly diagnosed multiple myeloma (NDMM). Participants will receive the combination of bortezomib, lenalidomide and dexamethasone (VRd) on a 3-week cycle until cycle 8, followed by the combination of lenalidomide and dexamethasone (Rd) on a 4-week cycle thereafter as per dosing schedule. Participants will receive belantamab mafodotin on a schedule that is dependent on the cohort to which they are assigned. This will be every cycle of VRd, every other cycle of VRd, or every third cycle of VRd. Belantamab may also be given as a 'split' dose, which is 50% of the dose on Day 1 and 50% of the dose on Day 8 of a cycle. Participants will complete an End of Treatment (EOT) visit at the point of study treatment discontinuation, followed by a Safety Follow-up visit 70 days after EOT.
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CANCER TYPE: Gastrointestinal
LOCATION: Edmonton
OPEN DATE: 27-Oct-20
MK3475-975
A Randomized, Double-blind, Placebo-controlled Phase 3 Trial of Pembrolizumab (MK-3475) Versus Placebo in Participants with Esophageal Carcinoma Receiving Concurrent Definitive Chemoradiotherapy (KEYNOTE 975)
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 07-Oct-20
AZ D5169C00001 (FLAURA2)
A Phase III, Open-label, Randomized Study of Osimertinib with or without Platinum Plus Pemetrexed Chemotherapy, as First-line Treatment in Patients with Epidermal Growth Factor Receptor (EGFR) Mutation- Positive, Locally Advanced or Metastatic Non-small Cell Lung Cancer
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CANCER TYPE: Breast
LOCATION: Edmonton
OPEN DATE: 02-Oct-20
SGNTUC-016 (HER2CLIMB02)
Randomized, double-blind, phase 3 study of tucatinib or placebo in combination with ado-trastuzumab emtansine (T-DM1) for subjects with unresectable locally-advanced or metastatic HER2+ breast cancer
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CANCER TYPE: Head and Neck
LOCATION: Edmonton
OPEN DATE: 02-Oct-20
GSK 209227
A Randomized, Double-Blind, Adaptive, Phase II/III Study of GSK3359609 in Combination with Pembrolizumab and 5FU-Platinum Chemotherapy versus Placebo in Combination with Pembrolizumab plus 5FUPlatinum Chemotherapy for First-Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 02-Oct-20
ARRAY-818-103
This is an open-label, 3-arm, fixed-sequence study to evaluate the effect of single and multiple oral doses of encorafenib in combination with binimetinib on the single oral dose pharmacokinetics (PK) of cytochrome P450 (CYP) enzyme probe substrates using a probe cocktail, on an organic anion-transporting polypeptide/breast cancer resistance protein (OATP/BCRP) substrate using rosuvastatin and on a CYP2B6 substrate using bupropion. The effect of multiple oral doses of the moderate cytochrome P450 (CYP) inhibitor modafinil on encorafenib in combination with binimetinib will also be assessed. The study will have 2 treatment phases, a drug-drug interaction (DDI) phase followed by a post-DDI phase.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 30-Sep-20
CCTG PM.1
Cancer drugs which target the effects of abnormal gene changes are called 'targeted therapies'. This study, called PM.1 or CAPTUR, will include some targeted therapies that are currently available. The purpose of this study is to find out what are the effects on a patient and their cancer when they are given a targeted therapy drug that is specific to an abnormal gene change in their cancer.
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CANCER TYPE: Gynecology
LOCATION: Edmonton
OPEN DATE: 21-Sep-20
IMGN853-0413
This Phase 3 study is designed to compare the efficacy and safety of mirvetuximab soravtansine vs. investigator's choice chemotherapy in patients with platinum-resistant high-grade epithelial ovarian cancer, primary peritoneal, or fallopian tube cancer, whose tumors express a high-level of FRα. Patients will be, in the opinion of the Investigator, appropriate for single-agent therapy for their next line of therapy. Folate receptor alpha (FRα) positivity will be defined by the Ventana FOLR1 (FOLR1-2.1) CDx assay.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 10-Sep-20
INCB 39110-309
The purpose of this study is to assess the efficacy and safety of itacitinib in combination with corticosteroids as first-line treatment for moderate or severe chronic graft-versus-host disease (cGVHD).
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 08-Sep-20
BMS CA209-8TT
Main Objective of this study is to examine long-term safety of nivolumab in participants on treatment and in follow up.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 28-Aug-20
TRIO039 BOLD-100
BOLD-100 is an intravenously administered sterile solution containing the ruthenium-based small molecule. BOLD-100 has been shown to preferentially decrease the expression of GRP78 in tumour cells and ER stressed cells when compared to normal cells. BOLD-100 will be combined with cytotoxic FOLFOX chemotherapy in this study, with a dose escalation cohort to ensure tolerability and safety, followed by a cohort expansion phase.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 21-Aug-20
CC92480-MM002
A Phase 1/2, Multicenter, Open-Label, Study to Determine the Recommended Dose and Regimen, and Evaluate the Safety and Preliminary Efficacy of CC- 92480 in Combination with Standard Treatments in Subjects with Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 14-Aug-20
(AstraZeneca) ENGOT – OV46 / DUO-O / D081RC00001
This is a Phase III randomised, double-blind, multi-centre study to evaluate the efficacy and safety of durvalumab in combination with standard of care platinum based chemotherapy and bevacizumab followed by maintenance durvalumab and bevacizumab or durvalumab, bevacizumab and olaparib in patients with newly diagnosed advanced ovarian cancer.
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CANCER TYPE: Gastrointestinal
LOCATION: Edmonton
OPEN DATE: 30-Jul-20
BMS CA209-9DW
The main purpose of this study is to compare the overall survival (OS) of nivolumab plus ipilimumab versus standard of care (SOC) (sorafenib or lenvatinib) in all randomized participants with advanced hepatocellular carcinoma (HCC) who have not received prior systemic therapy.
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 20-Jul-20
(NRG) GU-002
This randomized phase II/III trial studies docetaxel, antiandrogen therapy, and radiation therapy to see how well it works compared with antiandrogen therapy and radiation therapy alone in treating patients with prostate cancer that has been removed by surgery. Androgen can cause the growth of prostate cells. Antihormone therapy may lessen the amount of androgen made by the body. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving antiandrogen therapy and radiation therapy with or without docetaxel after surgery may kill any remaining tumor cells.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 17-Jul-20
ACE-LY-003
An Open-label, Phase 1b/2 Study of Acalabrutinib Alone or in Combination Therapy in Subjects with B-cell Non-Hodgkin Lymphoma
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CANCER TYPE: Blood and Marrow Transplant
LOCATION: Calgary
OPEN DATE: 26-Jun-20
(Dr. Storek) ATG2017 IIT
The purpose of this study is to find out whether compared to our standard low dose ATG with CSA, the high dose ATG without CSA minimizes the chances of relapse and chronic GVHD, without increasing the chances of other transplant complications.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 25-Jun-20
AALL1732
A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 24-Jun-20
AALL1631
This randomized phase III trial studies how well imatinib mesylate and combination chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia. Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving imatinib mesylate and combination chemotherapy may work better in treating patients with Philadelphia chromosome positive acute lymphoblastic leukemia.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 19-Jun-20
Geron MDS- IMERGE study
The purpose of this study is to evaluate the efficacy and safety of imetelstat in transfusion dependent participants with low or intermediate-1 risk myelodysplastic syndrome (MDS) that is relapsed/refractory to erythropoiesis-stimulating agent (ESA) treatment. Conducted at the University of Alberta Hospital.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 15-Jun-20
(AstraZeneca) D8220C00008 \ ACE-CL-312
This is a single arm study in which participants will be enrolled into 3 cohorts. In the treatment-naive (TN) cohort, a minimum of 300 participants with treatment-naïve chronic lymphocytic leukemia will be enrolled. In the relapsed/refractory (R/R) cohort, approximately 200 participants with relapsed/refractory chronic lymphocytic leukemia will be enrolled. In the prior Bruton tyrosine kinase inhibitor (BTKi) therapy cohort, up to 70 to 100 participants with Prior BTKi therapy will be enrolled
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 10-Jun-20
D910CC00001
COLUMBIA-1 is a Phase 1b/2, open-label, multicenter, randomized, multidrug platform study to evaluate the safety and efficacy of standard of care (FOLFOX plus bevacizumab) in combination with novel oncology therapies in patients with first-line metastatic MSS-CRC. The study is designed to concurrently evaluate potential novel combinations with clinical promise using a 2-part approach. Part 1 is a Phase 1b study of safety, and Part 2 is a Phase 2 study of efficacy and safety.
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 27-May-20
(Merck) MK-3475-966
This is a study of pembrolizumab plus gemcitabine/cisplatin versus placebo plus gemcitabine/cisplatin as first-line therapy in participants with advanced and/or unresectable biliary tract carcinoma. The study has 2 primary hypotheses: 1. Pembrolizumab plus gemcitabine/cisplatin is superior to placebo plus gemcitabine/cisplatin with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 by blinded independent central review (BICR) and 2. Pembrolizumab plus gemcitabine/cisplatin is superior to placebo plus gemcitabine/cisplatin with respect to overall survival (OS).
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 20-May-20
PCYC-1143-CA
This Phase 3 multinational, randomized, double-blind study is designed to compare the efficacy and safety of the combination of ibrutinib and venetoclax vs. ibrutinib and placebo in subjects with MCL.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 30-Mar-20
GMI-1271-301
A Phase III Randomized, Double-Blind Trial to Evaluate the Efficacy of Uproleselan Administered with Chemotherapy versus Chemotherapy Alone in Patients with Relapsed/Refractory Acute Myeloid Leukemia. Conducted at the University of Alberta Hospital.
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CANCER TYPE: Head and Neck
LOCATION: Edmonton
OPEN DATE: 19-Mar-20
Nivo Plus
The purpose of this study is to find out what effects the combination of Nivolumab and Pemetrexed has on you and your cancer. The safety of this combination and the effectiveness of this treatment will be studied.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 17-Mar-20
74494550AML-1003
An Open-label, Multicenter, Phase 1b Study of JNJ-74494550 (Cusatuzumab; Anti-CD70 Monoclonal Antibody) in Combination with Background Therapy for the Treatment of Subjects with Acute Myeloid Leukemia. Conducted at the University of Alberta Hospital.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 02-Mar-20
BMS CA031-002
The purpose of this study is to determine whether BMS-986258 both by itself and in combination with Nivolumab is safe and tolerable in the treatment of advanced malignant tumors
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CANCER TYPE: Gastrointestinal
LOCATION: Edmonton
OPEN DATE: 21-Feb-20
QBGJ098-301 PROOF
Infigratinib is an oral drug which selectively binds to fibroblast growth factor receptor (FGFR) 2 and is being developed to treat participants with FGFR2 mutated cholangiocarcinoma. The purpose of the study is to evaluate the efficacy and safety of the investigational agent oral infigratinib vs standard of care chemotherapy (gemcitabine plus cisplatin) in first-line treatment of participants with unresectable locally advanced or metastatic cholangiocarcinoma with FGFR2 gene fusions/translocations. Subjects will be randomized 2:1 to receive infigratinib or gemcitabine plus cisplatin
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CANCER TYPE: Neuroendocrine
LOCATION: Edmonton
OPEN DATE: 20-Feb-20
DX-GAL-001
A Phase I/II Study of Gallium-68 HA-DOTATATE ([68]Ga-HA-DOTATATE) in Patients with Known or Suspected Somatostatin Receptor Positive Tumours
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CANCER TYPE: Lung
LOCATION: Calgary
OPEN DATE: 11-Feb-20
(AZ) D9103C00001/PACIFIC-4/RTOG-3515
This is a phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab versus placebo following standard of care stereotactic body radiotherapy in patients with unresected clinical stage I/II lymph node-negative (T1 to T3N0M0) non-small cell lung cancer.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 07-Feb-20
CA209-73M
The purpose of the study is to assess the effectiveness of re-induction with Nivolumab combined with ipilimumab.
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 31-Jan-20
(CCTG) MAC.24 / S1418 / BR006 / MK-3475-242
This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery and have fewer side effects.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 02-Jan-20
GSK 204653
A phase I, open-label, dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of GSK3326595 in subjects with solid tumors and non-Hodgkin’s lymphoma
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 19-Dec-19
(Sanofi) ACT16105
A randomized phase II trial of SAR439859, a new SERD compound, versus fulvestrant in patients with hormone-receptor positive, HER2 negative locally advanced or metastatic breast cancer with prior exposure to hormonal therapies
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 06-Dec-19
AbbVie M14-239
This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage 2).
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 06-Dec-19
(CCTG) MAC.23 / Alliance A221505 / RT CHARM
This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery and have fewer side effects.
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 04-Dec-19
TPX-0005-01
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement.
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 28-Nov-19
(Merck) MK-3475-905 / KEYNOTE-905
A global, randomized phase III study to evaluate perioperative pembrolizumab with radical cystectomy + pelvic lymph node dissection (RC+PLND) versus RC+PLND alone in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC). This study is designed to assess the antitumor efficacy and safety of perioperative pembrolizumab compared with the current standard of care (cystectomy alone) for participants with muscle-invasive urothelial carcinoma who are ineligible for cisplatin-based chemotherapy
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 27-Nov-19
CA 030 001
The purpose of this study is to determine whether BMS-986249 both by itself and in combination with Nivolumab is safe and tolerable in the treatment of advanced solid tumors
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 26-Nov-19
AALL1731
A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy)
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CANCER TYPE: Gastrointestinal
LOCATION: Edmonton
OPEN DATE: 11-Nov-19
CA209 8HW
The main purpose of this study is to compare the clinical benefit, as measured by Progression-Free Survival (PFS), Objective Response Rate (ORR), and Overall Survival (OS), achieved by nivolumab in combination with ipilimumab or by nivolumab monotherapy in patients with Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) metastatic colorectal cancer.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 10-Nov-19
ARST1431
A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864, IND#122782) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS)
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 08-Nov-19
(CCTG) ALC.6
This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Monoclonal antibodies, such as inotuzumab ozogamicin, may block cancer growth in different ways by targeting certain cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia.
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 07-Nov-19
(Merck) MK-7339-001 / ENGOT-ov43 /KEYLYNK-001 / 194619
A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First-Line Treatment of BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC)
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 07-Nov-19
(Pfizer) C3441021 / TALAPRO-2
This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 05-Nov-19
CACZ885T2301
The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).
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CANCER TYPE: Cutaneous
LOCATION: Calgary
OPEN DATE: 31-Oct-19
(Incyte) INCMGA 0012-201/PODIUM 201
The purpose of this study is to assess the clinical activity and safety of INCMGA00012 in participants with advanced/metastatic Merkel cell carcinoma (MCC).
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 30-Oct-19
D9108C00001 (COAST)
The primary purpose of the study is to compare the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II -IIIA and the subset of IIIB (T>5cm N2 disease) completely resected (R0) non-small cell lung cancer (NSCLC).
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CANCER TYPE: Gynecology
LOCATION: Edmonton
OPEN DATE: 30-Oct-19
KCP-330-024
Patients with primary stage IV or recurrent disease who are in partial or complete response after having completed a single line of at least 12 weeks of taxane-platinum combo therapy will be randomized to selinexor or placebo until disease progression.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 22-Oct-19
R1979-ONC-162
An open-label study to assess the anti-tumor activity and Safety of regn1979, an anti-cd20 x anti-cd3 bispecific Antibody, in patients with relapsed or refractory Follicular lymphoma
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CANCER TYPE: Multiple Tumour Group
LOCATION: Calgary
OPEN DATE: 22-Oct-19
(Amgen) 20180143
To evaluate the safety and tolerability of AMG 404, a monoclonal antibody that binds to PD-1 and inhibits its engagement with ligands, in patients with advanced solid tumors.
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 09-Oct-19
(Merck) MK-3475-866 / KEYNOTE-866
A global study to evaluate peri-operative pembrolizumab with chemotherapy versus placebo to pembrolizumab plus chemotherapy in cisplatin eligible patients.
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CANCER TYPE: Head and Neck
LOCATION: Edmonton
OPEN DATE: 08-Oct-19
RTOG 3507
This phase II trial with a safety run-in component will evaluate whether the addition of pembrolizumab to Stereotactic Body Radiation Therapy (SBRT) re-irradiation will improve the progression-free survival for patients with recurrent or new second primary Head and Neck Squamous Cell Carcinoma (HNSCC).
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 02-Oct-19
20170543
Evaluate the safety and tolerability of AMG 510 in adult subjects with KRAS p.G12C mutant solid tumors. Estimate the maximum tolerated dose (MTD) and/or a biologically active dose (eg, recommended phase 2 dose [RP2D]) within investigated subject population groups.
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 27-Sep-19
D933QC00001
This is a Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with LS-SCLC Who Have Not Progressed Following Concurrent Chemoradiation Therapy
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 25-Sep-19
PCYC-1145-LT
Multicenter, open-label, prospective treatment protocol that provides continued access to ibrutinib to subjects who have completed parent ibrutinib studies, are still benefitting from treatment with ibrutinib, and have no access to commercial ibrutinib for their underlying disease within their region.
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 18-Sep-19
(CCTG) REC.4 / EA8143
A Phase 3 Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients With Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)
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CANCER TYPE: Cutaneous
LOCATION: Calgary
OPEN DATE: 13-Sep-19
(Sanofi) TCD14678
A Phase 1/1b first-in-human dose escalation and expansion study for the evaluation of safety, pharmacokinetics, pharmacodynamics and anti-tumor activity of SAR439459 administered intravenously as monotherapy and in combination with REGN2810 in adult patients with advanced solid tumors
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 12-Sep-19
1948-CL-0101
Targeting an Immune Modulatory Receptor, in subjects with Advanced Solid Tumors (i.e., non-small cell lung cancer (NSCLC), metastatic castration-resistant prostate cancer (mCRPC), ovarian cancer, melanoma and breast cancer, squamous cell carcinoma of the head and neck (SCCHN), etc.)
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 10-Sep-19
(Janssen) CR108598 / 54767414MMY2065
The purpose of this study is to compare the efficacy (rate of very good partial response [VGPR] or better as best response as defined by the International Myeloma Working Group [IMWG] criteria) of daratumumab subcutaneous (Dara-SC) in combination with carfilzomib and dexamethasone (Kd) with the efficacy of Kd in participants with relapsed refractory multiple myeloma who were previously exposed to daratumumab intravenous (Dara-IV) to evaluate daratumumab retreatment
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 04-Sep-19
(Clovis) CO-338-063 / TRITON 3
The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.
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CANCER TYPE: Breast
LOCATION: Edmonton
OPEN DATE: 28-Aug-19
DHA-WIN
Docosahexaenoic acid (DHA) for Women with Breast Cancer in the Neoadjuvant Setting
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 15-Aug-19
AGCT1532
The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 06-Aug-19
MK7339-010
Phase 3, Randomized, Open-label Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Participants with Metastatic Castration-resistant Prostate Cancer (mCRPC) Who are Unselected for Homologous Recombination Repair Defects and Have Failed Prior Treatment with One Next-generation Hormonal Agent (NHA) and Chemotherapy
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CANCER TYPE: Sarcoma
LOCATION: Edmonton
OPEN DATE: 01-Aug-19
DCC-2618-03-002
This study is a global, open-label Phase 2a/2b study to determine the efficacy and safety of KRT-232. In Part A of the study, patients will be randomly assigned to 5 arms with 2 different doses and 3 different dosing schedules of KRT 232. In Part B of the study, patients will be randomized either to treatment with KRT-232 administered at the recommended dose and schedule from Part A or to treatment with ruxolitinib.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 25-Jul-19
SCH ACCL1333 BMS CV185-155
The purpose of this study is to compare the effect of a blood thinning drug called Apixaban versus no administration of a blood thinning drug, in preventing blood clots in children with leukemia or lymphoma. Patients must be receiving chemotherapy, including asparaginase, and have a central line (a catheter inserted for administration of medications and blood sampling)
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CANCER TYPE: Melanoma
LOCATION: Edmonton
OPEN DATE: 03-Jul-19
MK3475-630
This is a randomized, double-blind, study that compares pembrolizumab with placebo given as adjuvant therapy in participants with high-risk locally advanced cutaneous squamous cell carcinoma (LA cSCC) that have undergone surgery with curative intent in combination with radiotherapy. The primary hypothesis is that pembrolizumab is superior to placebo in increasing recurrence free survival (RFS).
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 03-Jul-19
(Celgene) BB2121-MM-003
This is a multicenter, randomized, open-label, Phase 3 study comparing the efficacy and safety of bb2121 versus standard regimens in subjects with relapsed and refractory multiple myeloma (RRMM).
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CANCER TYPE: Breast
LOCATION: Edmonton
OPEN DATE: 02-Jul-19
DREAM
Diet Restriction and Exercise-induced Adaptations in Metastatic Breast Cancer
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CANCER TYPE: Head and Neck
LOCATION: Edmonton
OPEN DATE: 02-Jul-19
MK 3475-689
This is a randomized, active-controlled, open-label study of pembrolizumab (Pembro) given prior to surgery and pembrolizumab in combination with standard of care radiotherapy (with or without cisplatin), as post-surgical therapy in treatment naïve participants with newly diagnosed Stage III/IVA, resectable, locoregionally advanced, head and neck squamous cell carcinoma (LA-HNSCC). Efficacy outcomes will be stratified by programmed cell death ligand 1 (PD-L1) combined positive score (CPS) status. The primary hypothesis is that pembrolizumab given before surgery and after surgery in combination with radiotherapy (with or without cisplatin) improves major pathological response and event-free survival compared to radiotherapy (with or without cisplatin) given after surgery alone.
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CANCER TYPE: Neuro
LOCATION: Calgary
OPEN DATE: 28-Jun-19
(Exelixis) XL184-311/COSMIC-311
The objective of this study is to evaluate the effect of cabozantinib compared with placebo on progression free survival (PFS) and objective response rate (ORR) in subjects with Radioiodine-Refractory Differentiated Thyroid Cancer (DTC) who have progressed after prior VEGFR-Targeted therapy.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 28-Jun-19
(GSK) 205207 DREAMM 4
A Phase I/II Single Arm Open-Label Study to Explore Safety and Clinical Activity of GSK2857916 Administered in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Multiple Myeloma (DREAMM 4)
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 27-Jun-19
BI1381-0009
An open-label, Phase II, platform trial evaluating safety and efficacy of multiple BI 754091 anti-PD-1 based combination regimens in PD-(L)1 naïve and PD-(L)1 pretreated patient populations with advanced and/or metastatic solid tumours who have had at least one line of systemic therapy.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 21-Jun-19
MCRN007
Determine the tolerability of incorporating bortezomib and vorinostat into an ALL chemotherapy backbone for newly diagnosed infants with ALL.
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 05-Jun-19
(Clovis) CO-338-087 / GOG-3020 / ENGOT-ov45/NCRI/ATHENA
This is a Phase 3, randomized, multinational, double-blind, dual placebo-controlled, 4-arm study evaluating rucaparib and nivolumab as maintenance treatment following response to front-line treatment in newly diagnosed ovarian cancer patients. Response to treatment will be analyzed based on homologous recombination (HR) status of tumor samples.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 05-Jun-19
Headstart
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation With Randomization to Either Single Cycle or to Three Tandem Cycles of Marrow-Ablative Chemotherapy With Autologous Hematopoietic Progenitor Cell Rescue
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CANCER TYPE: Breast
LOCATION: Edmonton
OPEN DATE: 31-May-19
MK 3475-756
A Randomized, Double-Blind, Phase III Study of Pembrolizumab versus Placebo in Combination with Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy for the Treatment of High-Risk Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2–) Breast Cancer (KEYNOTE-756)
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 31-May-19
(Kartos Therapeutics Inc.) KRT-232-101
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study is a global, open-label Phase 2 study to determine the efficacy and safety of KRT-232 in patients with primary MF, post-polycythemia vera MF, or post-essential thrombocythemia MF who have failed previous treatment with JAK inhibitor (Part A), or Ruxolitinib (Part B). In Part A of the study, patients will be randomly assigned to 2 different doses and 2 different dosing schedules of KRT-232. In Part B of the study, patients will be treated at the recommended dose and schedule from Part A.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 23-May-19
CC-95251-ST-001
Study CC-95251-ST-001 is an open-label, Phase 1, dose escalation (Part A) and expansion (Parts B and C), first-in-human clinical study of CC-95251 in subjects with advanced cancers.
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CANCER TYPE: Lung
LOCATION: Calgary
OPEN DATE: 14-May-19
(Princess Margaret Cancer Centre) 18-5353 / VALUE
Current guidelines in non-small cell lung cancer recommend genomic assessment for mutations in EGFR and BRAF, gene rearrangements in ALK and ROS1, and resistance mutations such as T790M upon progression during EGFR inhibitor therapy. However, obtaining sufficient tumour tissue to test for these molecular alterations, as well as those with emerging targeted therapies, is challenging in lung cancer. A promising method to improve molecular diagnostic testing in lung and other cancers is the use of circulating cell-free DNA (cfDNA) obtained from blood samples or liquid biopsies. This multi-centre prospective study will compare blood-based profiling (using the GUARDANT360 assay) to standard of care tissue-based profiling within the Canadian system.
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 14-May-19
(Roche) BO40747
This study (also known as IMpassion050) will evaluate the efficacy and safety of atezolizumab compared with placebo when given in combination with neoadjuvant dose-dense anthracycline (doxorubicin + cyclophosphamide) followed by paclitaxel + trastuzumab + pertuzumab (ddAC-PacHP) in patients with early HER2-positive breast cancer (T2-4, N1-3, M0).
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CANCER TYPE: Lung
LOCATION: Calgary
OPEN DATE: 10-May-19
(AstraZeneca) D5084C00007 / SAVANNAH
A Phase II, Single Arm Study Assessing Efficacy of Osimertinib With Savolitinib in Patients With EGFRm+ MET+, Locally Advanced or Metastatic Non Small Cell Lung Cancer Who Have Progressed Following Osimertinib Treatment (SAVANNAH Study)
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 10-May-19
(Celgene) ACE-536-MDS-002 / COMMANDS
A Phase 3, Open-Label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Naïve Subjects Who Require Red Blood Cell Transfusions
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 08-May-19
(Acerta Pharma BV) ACE-CL-311 / D8221C00001
The purpose of this study is to evaluate the efficacy and safety of acalabrutinib in combination with venetoclax and acalabrutinib in combination with venetoclax with and without obinutuzumab compared to chemoimmunotherapy in subjects with previously untreated CLL.
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 08-May-19
(CCTG) CRC.8/ EA2165
This randomized phase II clinical trial studies how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells to grow and spread.
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CANCER TYPE: Head and Neck
LOCATION: Calgary
OPEN DATE: 07-May-19
(Ayala) AL-ACC-01 / ACCURACY
A Phase 2, Open-Label, Single-Arm, Multi-Center Study Of AL101 (BMS-906024) In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 03-May-19
SGNTV-001
Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 02-May-19
GSK205801
A Phase II, Randomized, Open-label Platform Trial Utilizing a Master Protocol to Study Novel Regimens Versus Standard of Care Treatment in NSCLC Participants
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 02-May-19
ALK 4230-A101
To better understand the safety and tolerability of ALKS 4230 in humans
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 22-Apr-19
(Astellas) 8951-CL-0302 / GLOW
The study is anticipated to randomize approximately 381 subjects with RRMM. Approximately 254 subjects will be randomized to Treatment Arm A and approximately 127 subjects will be randomized to Treatment Arm B.
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CANCER TYPE: Melanoma
LOCATION: Edmonton
OPEN DATE: 05-Apr-19
IIT-UNSCARRed
A Study to Evaluate the Efficacy and Safety of the Combined Use of Avelumab with Radiation Therapy for the Treatment of Unresectable Cutaneous Squamous Cell Carcinoma
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 01-Apr-19
(CCTG) OV.25 / STICs AND STONEs
A Randomized Phase II Double-Blind Placebo-Controlled Trial of Acetylsalicylic Acid (ASA) in Prevention of Ovarian Cancer in Women with BRCA 1/2 Mutations (STICs and STONEs)
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CANCER TYPE: Head and Neck
LOCATION: Edmonton
OPEN DATE: 19-Mar-19
OZM-088
The study is an open label, paucicentric, Phase I/II trial aiming to evaluate the safety, the clinical activity and abscopal anti-tumor effects of a therapeutic strategy associating Durvalumab in conjunction with SBRT or Durvalumab + Tremelimumab in conjunction with SBRT in patients with metastatic squamous cell carcinoma of head and neck, lung, or esophagus.
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 27-Feb-19
(BCCA) PanGen / H16-00291
Researchers are looking for better ways of understanding and treating pancreatic cancer. The purpose of this study is to see how useful it is to look for changes and characteristics in your genes (molecules that contain instructions for the development and functioning of the cells) and the genes within the tumour. These characteristics may be useful in choosing treatments for patients in the future. Changes (mutations) in genes have been shown to be an important characteristic in cancers. Looking at differences in genes in patients with advanced pancreatic ductal adenocarcinomas and comparing this information with response to their initial chemotherapy treatment may help to learn which treatments may be better for certain patients after initial treatment.
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CANCER TYPE: Melanoma
LOCATION: Edmonton
OPEN DATE: 26-Feb-19
CA 045 001
The purpose of the study is to test the effectiveness (how well the drug works), safety, and tolerability of the investigational drug called NKTR-214, when combined with nivolumab versus nivolumab given alone in participants with previously untreated melanoma skin cancer that is either unable to be surgically removed or has spread
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 25-Feb-19
CA027-002
The purpose of this study is to investigate experimental medication BMS-986253 in combination with Nivolumab in patients with advanced cancers.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 06-Feb-19
D933RC00001
A Global Study to Determine the Efficacy and Safety of Durvalumab in Combination with Gemcitabine+Cisplatin for Neoadjuvant Treatment and Durvalumab Alone for Adjuvant Treatment in Patients with Muscle-Invasive Bladder Cancer
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 29-Jan-19
AHEP1531
This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving combination chemotherapy may kill more tumor cells than one type of chemotherapy alone.
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CANCER TYPE: Radiation Therapy
LOCATION: Edmonton
OPEN DATE: 21-Dec-18
FINE ART
A novel nutritional supplement has been shown in previous studies to protect patients from treatment side effects while also improving the benefit of chemotherapy. This same supplement has been shown to slow or stop muscle loss in cancer patients, improving their daily function and quality of life. These results have been found in small studies; therefore larger, well-designed studies are required so that the results can be confirmed and translated to a clinical practice setting. Our research study at the Cross Cancer Institute aims to confirm whether this novel nutrient, along with chemotherapy or immunotherapy, can improve the benefit of treatment while preserving muscle and function for patients.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 20-Dec-18
D933SC00001 (AZ Nile)
This is a randomized, open-label, controlled, multi-center, global Phase III study to determine the efficacy and safety of combining durvalumab ± tremelimumab with standard of care (SoC) chemotherapy (cisplatin + gemcitabine or carboplatin + gemcitabine doublet) followed by durvalumab monotherapy versus SoC alone as first-line chemotherapy in patients with histologically or cytologically documented, unresectable, locally advanced or metastatic transitional cell carcinoma of the urothelium (including renal pelvis, ureters, urinary bladder, and urethra).
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 27-Nov-18
SPI-POZ-202
This is a Phase 2, open-label, multi-center study to evaluate the efficacy and the safety/tolerability of poziotinib in seven patient cohorts for up to 603 previously treated and treatment-naïve NSCLC patients. Cohorts 3 and 4 were added with Amendment 1 and three additional cohorts were added with Amendment 2 (Cohorts 5, 6 and 7).
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 27-Nov-18
(CCTG) MA.39 / TAILOR RT
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 21-Nov-18
(AMGEN) 20150161
A Phase 1 First in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 176 in Subjects With Relapsed or Refractory Multiple Myeloma and Subjects With Relapsed or Refractory Acute Myeloid Leukemia
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CANCER TYPE: Gastrointestinal
LOCATION: Edmonton
OPEN DATE: 08-Nov-18
8951- CL-0301
A Phase 3, Global, Multi-Center, Double-Blind, Randomized, Efficacy Study of Zolbetuximab (IMAB362) Plus mFOLFOX6 Compared with Placebo Plus mFOLFOX6 as First-line Treatment of Subjects with Claudin (CLDN)18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
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CANCER TYPE: Head and Neck
LOCATION: Edmonton
OPEN DATE: 07-Nov-18
CCTG HN.9
Sometimes, cancer patients receive an initial treatment, followed by additional treatment to lower the chance of cancer coming back. The standard or usual treatment for this type of disease is initially having radiation therapy at the same time as chemotherapy (with a drug called cisplatin), with no additional therapy afterwards
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CANCER TYPE: Radiation Therapy
LOCATION: Edmonton
OPEN DATE: 25-Oct-18
ReRAD
Phase 2 will determine the confirmed Overall Response Rate (ORR) as assessed by Blinded Independent Central Review (BICR) of repotrectinib in each subject population expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. The secondary objective will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS) and clinical benefit rate (CBR) of repotrectinib in each expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 22-Oct-18
(Sunnybrook Research Institute) 0891 / SPIREL
This is a Phase 2 non-randomized, open label, uncontrolled, efficacy and safety study. Study participants will receive two priming doses of 0.5mL of DPX-Survivac 21 days apart and up to six 0.1ml maintenance injections every two months with low dose metronomic oral cyclophosphamide (50 mg BID) for one year or until disease progression, whichever occurs first. Pembrolizumab 200 mg will be administered every 3 weeks for up to one year or until disease progression, whichever occurs first.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 26-Sep-18
MOR208C204
The purpose of the study is to compare the safety and efficacy of Tafasitamab with BEN versus RTX with BEN in adult patients with relapsed of refractory DLBCL.
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CANCER TYPE: Neuro
LOCATION: Calgary
OPEN DATE: 25-Sep-18
(CCTG) CE.7
A Phase III Trial of Stereotactic Radiosurgery Compared With Whole Brain Radiotherapy (WBRT) for 5-15 Brain Metastases
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 24-Sep-18
NRG-GU005 / HYPORT
This randomized phase III trial studies how well stereotactic body radiation therapy works compared to intensity-modulated radiation therapy in treating patients with stage IIA-B prostate cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Stereotactic body radiation therapy is a specialized radiation therapy that sends x-rays directly to the tumor using smaller doses over several days and may cause less damage to normal tissue. Stereotactic body radiation therapy may work better in treating patients with prostate cancer.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 18-Sep-18
IIT Imatinib-CCI-PH1-01
A Phase I Dose Escalation Trial to Determine if Imatinib Treatment Restores Sodum Iodide Symporter Function and Sensitivity to Radioiodin Treatment in Metastatic Thyroid Cancer Patients
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 05-Sep-18
(ImmunoVaccine) ONC-DPX-Survivac-06
T cell activating therapy DPX-Survivac, low dose oral cyclophosphamide, and IDO1 inhibitor epacadostat will be tested together for the first time in patients with recurrent ovarian, fallopian tube, or peritoneal cancer to determine the safety and potential immune-modulating activity of the combination of these agents.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 30-Aug-18
CPI-0610
Phase 1 Part (Complete): Open-label, sequential dose escalation study of CPI-0610 in patients with previously treated Acute Leukemia, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasms, and Myelofibrosis.Completed this Part prior to start. Phase 2 Part: Open-label study of CPI-0610 with and without Ruxolitinib in patients with Myelofibrosis. CPI-0610 is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins. Conducted at the University of Alberta Hospital.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 17-Aug-18
Bayer 18594
We hypothesize that the use of rRT will be feasible (physicians will be willing to offer rRT, patients will be willing to undergo rRT, and courses of rRT will be able to completed in a timely manner [per the usual schedule of 5 days a week]), safe (patients will experience few, if any, grade 3 [severe] or grade 4 [life-threatening] toxicities), and effective in prolonging life (that we will be able to increase the median survival after progression from 3 months [offering symptom control only] to 6 months [offering rRT and symptom control] compared to an historic cohort).
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CANCER TYPE: Genitourinary
LOCATION: Calgary
OPEN DATE: 30-Jul-18
(CUOG) PRIME
This is a multi-centre, double-blind, randomized phase III trial comparing metformin to placebo in patients with advanced prostate cancer starting androgen deprivation therapy.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 14-Jun-18
KEYNOTE-651
A Phase 1b Multi-cohort Study of the Combination of Pembrolizumab (MK-3475) plus Binimetinib alone or the Combination of Pembrolizumab plus Chemotherapy with or without Binimetinib in Participants with Metastatic Colorectal Cancer
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 24-May-18
(Celgene) CC-92480-MM-001
This is an open-label, multi-center, international, Phase 1 study to assess the safety, PK/PD and preliminary efficacy of CC-92480 in combination with dexamethasone in subjects with RRMM.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 26-Apr-18
CCTG IND 234
The purpose of the pre-study screening is to test for DNA abnormalities or biomarkers.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 20-Apr-18
ALTE16C1
This research trial studies saliva, semen, and blood samples to determine effects of chemotherapy on fertility in osteosarcoma survivors. Study biospecimen samples from osteosarcoma survivors in the laboratory may help doctors learn whether chemotherapy causes fertility problems and to learn more about the long term effects.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 10-Apr-18
CCTG IND.223
The purpose of this study is to find out what effects a new drug, palbociclib, has on prostate cancer and will look at the side effects of treatment with palbociclib. The researchers doing this study are also interested in looking for markers that may help predict which patients are most likely to be helped by palbociclib and to see how the cancer cells respond to palbociclib.
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 04-Apr-18
(Basilea) DZB-CS-301
This pivotal, open-label, single-arm study will evaluate the anti-cancer activity of derazantinib by Objective Response Rate (ORR) by central radiology review as per RECIST v1.1 in subjects with inoperable or advanced intrahepatic cholangiocarcinoma (iCCA) whose tumors harbor FGFR2 gene fusions (by FISH performed by the central laboratory) or FGFR2 gene mutations or amplifications (based on NGS testing performed or commissioned by the respective study center) and who received at least one prior regimen of systemic therapy. Subjects will be dosed orally once per day at 300 mg of derazantinib capsules.
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 20-Mar-18
AZ D6185C00001
This is an open-label, multi-centre, umbrella Phase II study in patients with metastatic NSCLC who have progressed on an anti-PD-1/PD-L1 containing therapy. This study is modular in design, allowing initial assessment of the efficacy, safety, and tolerability of multiple treatment arms.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 18-Mar-18
CV202-103
This is a Phase 1b/2, open-label, 2-part, multicenter trial to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of BMS-813160 in combination with either FOLFIRI, gemcitabine (Gem)/nab-paclitaxel (ABRAXANE), or nivolumab in participants with advanced CRC or pancreatic cancer.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 08-Mar-18
APEC14B1
This research trial studies the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 28-Feb-18
(Abbvie) M15-654
This is a study of venetoclax, daratumumab, and dexamethasone with and without bortezomib combination therapy to evaluate safety, tolerability, and efficacy of these combinations in participants with relapsed or refractory multiple myeloma. The study will consist of 2 distinct parts: Part 1 includes participants with t(11;14) positive relapsed/refractory (R/R) multiple myeloma who will receive venetoclax in combination with daratumumab and dexamethasone (VenDd); Part 2 includes participants with R/R multiple myeloma who will receive venetoclax in combination with daratumumab, bortezomib, and dexamethasone (VenDVd). Each Part will be initiated with a dose-escalation phase in which increasing doses of venetoclax will be given with fixed doses of daratumumab and dexamethasone (Part 1a) or with fixed doses of daratumumab, bortezomib, and dexamethasone (Part 2a). Each dose escalation phase will be followed by a single-arm, open-label expansion phase
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 23-Feb-18
ALTE15N2
This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treatments for high-risk neuroblastoma are better tolerated with less side effects over time.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 09-Feb-18
MK 4280-001-2003
This is a nonrandomized, multisite, open-label, dose-escalation study of MK-4280 monotherapy (Part A, Arm 1) and MK-4280 in combination with pembrolizumab (Part A, Arm 2) followed by a dose confirmation and efficacy evaluation of MK-4280 in combination with pembrolizumab (Part B) in subjects with a histologically or cytologically confirmed diagnosis of advanced solid tumors.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 02-Feb-18
AGCT1531
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors
 
CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 02-Feb-18
AGCT1531
This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 15-Jan-18
(AbbVie) P16-489 DEVOTE
Post-marketing observational study (PMOS) to describe the management and the use of healthcare resources in patients with chronic lymphocytic leukemia (CLL) initiating venetoclax in routine clinical practice (DEVOTE)
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 08-Jan-18
TINI
The purpose of this study is to test the good and bad effects of the study drugs bortezomib and vorinostat when they are given in combination with chemotherapy commonly used to treat acute lymphoblastic leukemia (ALL) in infants. For example, adding these drugs could decrease the number of leukemia cells, but it could also cause additional side effects. Bortezomib and vorinostat have been approved by the US Food and Drug Administration (FDA) to treat other cancers in adults, but they have not been approved for treating children with leukemia. With this research, we plan to meet the following goals:
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CANCER TYPE: Lung
LOCATION: Edmonton
OPEN DATE: 20-Dec-17
BO29554
A Phase II/III Multicenter Study Evaluating the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable Somatic Mutations Detected in Blood (B-FAST: Blood-First Assay Screening Trial)
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CANCER TYPE: Multiple Tumour Group
LOCATION: Calgary
OPEN DATE: 17-Oct-17
(Astex) ASTX660-01
This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with advanced solid tumors or lymphoma for whom standard life-prolonging measures are not available.
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CANCER TYPE: Phase I
LOCATION: Edmonton
OPEN DATE: 17-Jul-17
ESPS-001
The main purpose of this two-part study is to evaluate the safety and efficacy of the study drug known as LY2880070 in participants with advanced or metastatic solid tumors.
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 10-Jul-17
(Tesaro) 4010-01-001 / GARNET
A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an anti-PD-1 Monoclonal Antibody, in Patients with Advanced Solid Tumors
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CANCER TYPE: Gynecology
LOCATION: Calgary
OPEN DATE: 12-Jun-17
(UHN) OZM-058
This is a study that will look at the effects and how useful investigational drug olaparib is as a neoadjuvant treatment (treatment given as to shrink a tumor before the main treatment) prior to surgery in patients with recurrent ovarian, primary peritoneal or fallopian tube cancer.
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CANCER TYPE: Genitourinary
LOCATION: Edmonton
OPEN DATE: 19-May-17
MK 3475-365-0102
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in patients with metastatic castrate resistant prostate cancer (mCRPC). There will be four cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, and cohort D will receive pembrolizumab + abiraterone + prednisone. Outcome measures will be assessed individually for each cohort.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 27-Apr-17
AEWS1221
This randomized phase III trial studies how well combination chemotherapy with or without ganitumab works in treating patients with newly diagnosed Ewing sarcoma that has spread to other parts of the body. Immunotherapy with monoclonal antibodies, such as ganitumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as vincristine sulfate, doxorubicin hydrochloride, cyclophosphamide, ifosfamide, and etoposide phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether combination chemotherapy is more effective with or without ganitumab in treating patients with newly diagnosed Ewing sarcoma.
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CANCER TYPE: Radiation Therapy
LOCATION: Edmonton
OPEN DATE: 21-Mar-17
STOP-NSCLC
A multicenter randomized phase II trial of stereotactic body radiotherapy for oligo-progressive metastatic cancers. Eligible patients will be randomized in a 1:2 ratio between receiving their standard of care therapy or stereotactic ablative radiotherapy (SABR) to all sites of oligo-progressive lesions. Radiotherapy will be administered as soon as possible following randomization, and subjects will be followed until next disease progression. The primary outcome is progression-free survival (PFS).
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CANCER TYPE: Lung
LOCATION: Calgary
OPEN DATE: 17-Mar-17
(CCTG) IND.227
Pembrolizumab is a new type of drug for mesothelioma (immunotherapy). Laboratory tests show that this drug works by helping improve the body's immune response to help fight cancer. Pembrolizumab may help the immune system to recognize cancer cells and slow down the growth and/or spreading of cancer.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 16-Mar-17
OZM-063
This is an open-label, randomized, multi-center, comparator Phase II trial looking at the addition of Bevacizumab to Vinblastine in chemotherapy naïve pediatric patients with progressive Low Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm A or Arm B. Arm A includes 68 weeks of single agent Vinblastine administered once weekly IV. Arm B includes 68 weeks of Vinblastine administered weekly IV with the addition of 12 doses of Bevacizumab administered every two weeks IV for the initial 24 weeks. Randomization will take place at the time of registration taking into account NF1 and BRAF-KIAA1549-fusion status.
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CANCER TYPE: Melanoma
LOCATION: Edmonton
OPEN DATE: 16-Feb-17
CCTG ME 13
The purpose of this study is to compare the effects on patients with metastatic melanoma of taking a government approved and paid-for PD-1 inhibitor intermittently, with taking the same type of agent continuously. Researchers want to see if the two ways of giving this type of treatment work equally well in extending the life of patients with melanoma, or not.
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CANCER TYPE: Other
LOCATION: Edmonton
OPEN DATE: 23-Dec-16
ACE Study
The primary purpose of this proposed 5-year hybrid effectiveness and implementation study is to evaluate the relative benefit from, and implementation of an Alberta wide clinic-to-community-based cancer and exercise model of care - the Alberta Cancer Exercise (ACE) Program. The investigators hypothesize that the strategy will improve the physical well-being and QoL of survivors (on and off cancer treatment) while preventing the development of secondary cancers.
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 17-Nov-16
Stemline SL-401-0314
This multi-center, multi-arm trial is evaluating the safety and efficacy of tagraxofusp, a CD123-targeted therapy, in patients with either chronic myelomonocytic leukemia (CMML) or myelofibrosis (MF). There are two CMML cohorts, one enrolling patients with CMML (CMML-1 or CMML-2) who are refractory/resistant or intolerant to hypomethylating agents (HMA), hydroxyurea (HU), or intensive chemotherapy; and one enrolling treatment-naive patients with CMML (CMML-1 or CMML-2) with molecular features associated with poor prognosis. The MF cohort will enroll patients who are resistant/refractory or intolerant to approved JAK therapy (JAK1/JAK2 or JAK2). Conducted at the University of Alberta Hospital.
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 17-Nov-16
(Novartis) CRAD001YCA09 TreatER+ight
For patients with AML who cannot receive standard chemotherapy, azacitidine (also known as Vidaza®) is a current standard of care treatment option in the United States. This clinical study is testing an experimental medicine called ASP2215, also known as gilteritinib. Gilteritinib works by stopping the leukemia cells from making the FLT3 protein. This can help stop the leukemia cells from growing faster.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 11-Oct-16
POE16-01
The purpose of this study is to test the safety of neratinib at different dose levels and to find out what effects, good and bad, it has on the patients and the cancer.
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CANCER TYPE: Neuro
LOCATION: Calgary
OPEN DATE: 22-Sep-16
(CCTG) CEC.6
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.
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CANCER TYPE: Melanoma
LOCATION: Calgary
OPEN DATE: 06-Jun-16
(Amgen) 20120139
A Registry Study to Evaluate the Survival and Long-Term Safety of Subjects With Melanoma Who Previously Received Talimogene Laherparepvec
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CANCER TYPE: Hematology
LOCATION: Edmonton
OPEN DATE: 23-May-16
GH29914
The primary objective for this study is to assess the safety and tolerability as well as preliminary efficacy of venetoclax in combination with cobimetinib, and venetoclax in combination with idasanutlin in patients with relapsed or refractory acute myeloid leukemia (R/R) AML who are not eligible for cytotoxic therapy.
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 15-Apr-16
(AHS) APBI 27/5 / ACCEL
Accelerated Partial Breast Irradiation Using Five Daily Fractions: A Single Arm, Phase II, Prospective Cohort Study to Examine Cosmetic Outcomes and Toxicity (The ACCEL Trial)
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 07-Apr-16
SJMB12
Tumour Type Brain Tumour: Medulloblastoma - A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 04-Apr-16
NRG - BR002
This is a phase IIR/III, randomized, multicenter trial of standard of care therapy with or without stereotactic body radiotherapy (SBRT) and/or surgical ablation for patients with newly oligometastatic breast cancer.
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CANCER TYPE: Head and Neck
LOCATION: Calgary
OPEN DATE: 29-Feb-16
NRG - HN001
Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)
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CANCER TYPE: Breast
LOCATION: Calgary
OPEN DATE: 02-Feb-16
NRG - BR003
This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether doxorubicin hydrochloride and cyclophosphamide is more effective when followed by paclitaxel alone or paclitaxel and carboplatin in treating triple-negative breast cancer.
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CANCER TYPE: Multiple Tumour Group
LOCATION: Calgary
OPEN DATE: 14-Oct-15
RTOG 1112
This randomized phase III trial studies sorafenib tosylate and stereotactic body radiation therapy to see how well they work compared to sorafenib tosylate alone in treating patients with liver cancer. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Stereotactic body radiation therapy may be able to send the radiation dose directly to the tumor and cause less damage to normal tissue. Giving sorafenib tosylate together with stereotactic body radiation therapy may kill more tumor cells.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 11-Sep-15
(Karyopharm) KCP-330-017 / STOMP
This study will independently assess the efficacy and safety of 8 combination therapies in 9 arms, in dose-escalation/-evaluation and expansion phases, for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) and newly diagnosed multiple myeloma (NDMM). The combinations to be evaluated are:
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 27-Jul-15
ANBL1232
This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is necessary and what the best treatment is. Response and biology-based risk factor-guided therapy may be effective in treating patients with non-high risk neuroblastoma and may help to avoid some of the risks and side effects related to standard treatment
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 16-Jul-15
POE14-01
This study evaluates the use of carfilzomib in combination with cyclophosphamide and etoposide for children with relapsed/refractory solid tumors or leukemia. The medications cyclophosphamide and etoposide are standard drugs often used together for the treatment of cancer in children with solid tumors or leukemia.
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CANCER TYPE: Hematology
LOCATION: Calgary
OPEN DATE: 05-May-15
(CCTG) LY.17
The purpose of this study is to find out what effects new combinations of treatment will have this disease. In this clinical trial, the study treatment options currently are ibrutinib plus R-GDP, or R-GDP alone.
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CANCER TYPE: Blood and Marrow Transplant
LOCATION: Calgary
OPEN DATE: 14-Apr-15
(AHS) HDM-Gem-HDT-ASCT-Shafey GEMHDM2014
Infusional Gemcitabine and High-dose Melphalan Conditioning Prior to Autologous Stem Cell Transplantation for Patients with Relapsed/Refractory Lymphoma
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 20-Nov-14
ACNS0831
Tumour Type Brain Tumour: Ependymoma - Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly Diagnosed Ependymoma Ages 1 to 21 Years
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CANCER TYPE: Neuro
LOCATION: Calgary
OPEN DATE: 26-May-14
(RI MUHC) McG 1132
The purpose of this study is to determine whether a combination of Sunitinib, Temozolomide and Radiation Therapy would be effective in the treatment of newly diagnosed Glioblastoma patients harboring tumors with unmethylated MGMT promoter. Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma
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CANCER TYPE: Neuroendocrine
LOCATION: Edmonton
OPEN DATE: 29-Apr-14
TX-LUT-001
Neuroendocrine tumours (NETs) are rare, slow growing, and diagnosis is often delayed with advanced metastases at presentation. In select patient populations, radioisotope therapy with Lutetium-177 (Lu-DOTA-TATE) has been shown to be a safe and effective palliative therapy, and has been widely used by research groups in Europe. A brand of Lu-DOTA-TATE (Lutathera(R)) is approved for the treatment of gastroenteropancreatic NETs in Europe, the U.S., and more recently in Canada. While Lutathera(R) is approved in Canada, it is not available in Alberta yet. This study is being done to provide access to Lu-DOTA-TATE treatment for patients with somatostatin receptor positive tumours. Lu-DOTA-TATE has been used at the Cross Cancer Institute to treat more than 300 patients with NETs since August, 2010. Our Lu-DOTA-TATE treatment was initially given under Health Canada's Special Access Programme (SAP), with each individual treatment requiring separate approval. In 2014, Health Canada requested we conduct a clinical trial with Lu-DOTA-TATE instead.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 05-Aug-13
ALTE11C2
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment. Studying samples of blood in the laboratory from patients receiving dexrazoxane hydrochloride may help doctors learn more about the effects of dexrazoxane hydrochloride on cells. It may also help doctors understand how well patients respond to treatment.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 06-May-13
AALL1131
This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) and giving the drugs in different doses and in different combinations may kill more cancer cells.
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CANCER TYPE: Gastrointestinal
LOCATION: Calgary
OPEN DATE: 15-Jul-10
(CCTG) CO.21 / CHALLENGE
This randomized phase III trial is studying a physical activity program given together with health education materials to see how well it works compared with giving health education materials alone for patients who have undergone treatment for high-risk stage II or stage III colon cancer.
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CANCER TYPE: Oncologic Imaging
LOCATION: Edmonton
OPEN DATE: 30-Nov-08
CS-FAZ-005
A Pilot Study of the Role of 18F-FAZA in Combination with FluGlucoScan® Injection PET Scans in Assessing Early Functional Response in Patients with Inoperable Non-Small Cell Lung Cancer Undergoing Radiotherapy or Chemo-radiotherapy. (CS-FAZ-005)
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 15-Sep-08
ALTE07C1
This research trial studies neuropsychological (learning, remembering or thinking) and behavioral outcomes in children and adolescents with cancer by collecting information over time from a series of tests.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 02-Jan-06
AREN03B2
This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.
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CANCER TYPE: Pediatrics
LOCATION: Edmonton
OPEN DATE: 21-May-04
ALTE03N1
This clinical trial studies cancer survivors to identify those who are at increased risk of developing late-occurring complications after undergoing treatment for childhood cancer. A patient's genes may affect the risk of developing complications, such as congestive heart failure, heart attack, stroke, and second cancer, years after undergoing cancer treatment. Genetic studies may help doctors identify survivors of childhood cancer who are more likely to develop late complications.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: 29-Mar-01
ANBL00B1
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: N/A
AALL08B1
This research trial studies a risk-based classification system for patients with newly diagnosed acute lymphoblastic leukemia. Gathering health information about patients with acute lymphoblastic leukemia may help doctors learn more about the disease and plan the best treatment.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: N/A
ACNS1123
This phase II trial studies how well chemotherapy followed by radiation therapy work in treating younger patients with newly diagnosed central nervous system germ cell tumors that have not spread to other parts of the brain, spinal canal, or body (localized). Drugs used as chemotherapy, such as carboplatin, etoposide, and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x rays to kill tumor cells. Giving chemotherapy followed by radiation therapy may kill more tumor cells.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: N/A
AHEP0731
This phase III trial studies the side effects and how well risk-based therapy works in treating younger patients with newly diagnosed liver cancer. Surgery, chemotherapy drugs (cancer fighting medicines), and when necessary, liver transplant, are the main current treatments for hepatoblastoma. The stage of the cancer is one factor used to decide the best treatment. Treating patients according to the risk group they are in may help get rid of the cancer, keep it from coming back, and decrease the side effects of chemotherapy.
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CANCER TYPE: Pediatrics
LOCATION: Calgary
OPEN DATE: N/A
TOPAZ
This is a phase I, dose escalation study where topotecan will be administered at lower doses given more frequently on a prolonged schedule (low dose metronomic; LDM), in combination with pazopanib administered in a specific dose range. The maximum tolerated dose (MTD) and the recommended phase 2 dose (RP2D) will be evaluated for LDM topotecan in combination with pazopanib in children with recurrent or refractory solid tumours. Pharmacokinetic and pharmacodynamic studies will be conducted to further define the exposure to and activity of LDM topotecan in combination with pazopanib.
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